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however, a delay in barrier establishment of other TJ proteins including occludin and claudins in the TJ was observed, indicating that ZO proteins have a role to play in the regulation of TJ assembly (Umeda et al., 2004)

DCA has shown improvement in mPAP, right ventricular function, and mitochondrial respiration in animal models of PH, as well as functional capacity in patients with idiopathic pulmonary hypertension (IPAH) (Michelakis et al., 2017