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Nevertheless, PCLiS might serve as a human, close to in vivo reference model for development of less complex and more ubiquitously available cell models, such as 3D HepaRG spheroids (Seo et al

Indeed, astrocyte disruption has been identified as a major contributor to neuronal dysfunction

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The strategy of deficiency management aims to normalize the metabolic decompensation and primarily relies on the supplementation of VitB12 and on drugs targeting the reduction of toxic metabolite build-up

A routine that supports both the liver and cellular energy (NAD+) provides the best long-term results