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As expected, S100a8 was predominantly expressed in the PMN population ( Figure 2I ), and Cd3e predominantly in the T cell population ( Figure 2J )

BSA, bovine serum albumin

doi: 10.1016/s0092-8674(00)80208-1

Abbreviations AAD: American Academy of Dermatology ACD: Allergic contact dermatitis AD: Atopic dermatitis AFU: Adult fingertip units AST: Astaxanthin ASO: Anti-sense oligonucleotide BMV: Betamethasone valerate BSA: Body surface area CAT: COPD assessment tool CHEMS: Cholesteryl hemisuccinate COX-2: Cyclooxygenase-2 CR: Ceramide CsA: Cyclosporin A CS: Chitosan CTAB: Cetyltrimethylammonium bromide DNCB: 1-Chloro-2,4-dinitrobenzene DOPE: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DSPE: Distearoyl-phosphatidylethanolamine DSW: Dead sea water FLG: Filaggrin GCS: Global clinical severity GMS: Glycerylmonostearate GPx-1: Glutathione peroxidase-1 HB: Halobetasol propionate HC: Hydrocortisone HHCL: Hydroxyzine HCL HO-1: Heme oxygenase-1 iNOS: Inducible nitric oxide synthase INF-: Interferon-gamma IGA: Investigators global assessment IL-1: Interleukin-1 IL-1: Interleukin-1 IL-4: Interleukin-4 IL-5: Interleukin-5 IL-6: Interleukin-6 IL-8: Interleukin-8 IL-10: Interleukin-10 IL-12p70: Interleukin-12p70 IL-13: Interleukin-13 IL-18: Interleukin-18 IL-22: Interleukin-22 ITT: Intent to treat KLK: Kallikrein LCs: Langerhans cells MAPK: Mitogen-activated protein kinase MCGs: Membrane-coating granules MDLC: Langerhans cells (LCs) monocyte-derived LC-like cells MMP: Matrix metalloproteinase mRNA: Messenger ribonucleic acid MPO: Myeloperoxidase NLCs: Nano-lipid carriers NCs: Nanocapsules NE: Neutrophil elastase NF-B: Nuclear factor-kappa B NIC: Nicotinamide NPSH: Non-protein thiol OLA: Oleic acid ORG: Oregonin PASI: Psoriasis area and severity index PCL: Poly(-caprolactone) PEG: Poly(ethylene glycol) PGZ: Pioglitazone PLGA: Poly lactic-co-glycolic acid PNPs: Polymeric nanoparticles PVP: Poly vinyl pyrrolidone ROS: Reactive oxygen species SC: Stratum corneum SCORAD: Scoring atopic dermatitis SLNs: Solid lipid nanoparticles SUV: Small uni-lamellar vesicle StNC: Starch-based nanoparticulate system TCR: Tacrolimus TBARS: Thiobarbituric acid reactive species TMSNs: Mesoporous silica nanoparticles loaded with tacrolimus THC: Tetrahydrocurcumin TEOS: Tetraethyl orthosilicate TEWL: Transepidermal water loss Th: T helper TNF-: Tumor necrosis factor-alpha TSLP: Thymic stromal lymphopoietin TSS: Total sign score UVA: Ultraviolet A UVB: Ultraviolet B USFDA: United State Food and Drug administration VAS: Visual analogue scale VEGF: Vascular endothelial growth factor toADSI: Topical atopic dermatitis severity index vIGA-AD: Validated investigator global assessment for atopic dermatitis References Ghosh N, Mitra S, Banerjee ER

Because plasma tCys has been positively associated with fat mass in humans, we tested the hypothesis that decreased tCys in TgI278T Cbs / mice was the cause of the lean phenotype by placing the animals on water supplemented with N-acetyl cysteine (NAC) from birth to 240 days of age