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Predicting the efficacy of c-MET inhibitor in combination with ICI therapy The malfunction of MET affects the expression of PD-L1 in tumors through complex and varied pathways

GHK reversed the gene expression pattern so it became consistent with the activation of the TGF-beta pathway

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However, some of the widely used affinity tags, such as the His-tag, exhibit several drawbacks and limitations, since they can increase the risk of distorting the natural conformation of the target protein or necessitate stringent elution and wash conditions affecting the yield of the target protein