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[118] Lee CK, Jeong SH, Jang C, et al

Safety Study-Open Label Mania Safety Data In the two long-term (six month) safety studies in pediatric patients (n= 292) between the ages of 10 and 17 years old, no clinically meaningful differences in the adverse reaction profile were observed when compared to adults

Likewise, GO analysis demonstrated enrichment of extracellular matrix remodeling and fibrotic pathways, consistent with disease progression (Supplemental Figure 8)