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24 Patients metabolizing morphine to hydromorphone will typically exhibit hydromorphone concentrations under 6% of the morphine concentration in urine

Moosmayer, D., Hilpmann, A., Hoffmann, J., Schnirch, L., Zimmermann, K., Badock, V., Furst, L., Eaton, J.K., Viswanathan, V.S., Schreiber, S.L., Gradl, S., Hillig, R.C

Additionally, TBK1 regulates the phosphorylation states of SQSTM1/p62, OPTN, and NDP52, thereby enhancing their binding affinity to the ubiquitin chains and promoting mitochondrial elimination [64]