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Nat Commun 15 , 1733 (2024)

The use of GPX4 inhibitors in vivo (in living organisms) presents several challenges, particularly due to the risk of excessive systemic toxicity caused by nonselective inhibition of GPX4

This provides insight into the mechanism of taurine benefit through global RAAS suppression and similar to studies in hypertensive rats, suggests that benefit might be best realized in patients with the most baseline RAAS activation 27

After 30 min of reperfusion, total iron and Fe 2+ levels in the tissue were the highest, the LPO product MDA also accumulated with prolonged reperfusion time, the level of reduced GSH decreased, and the level of oxidized GSSG increased (Fig

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