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In the older population, both moderate aerobic and resistance exercise increases antioxidant reserves, reduces oxidative damage, and suppresses systemic inflammation [47,77]

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Given the profound changes in gene expression and ferroptosis-associated metabolite abundance in the CNS niche, we next used the C11-BODIPY sensor 22 to investigate whether there were diaerences in basal levels of lipid peroxidation between ALL cells resident in the bone marrow or CNS compartment ( Figure 2A )

380 The E3 ubiquitin ligase Dsc, which has been shown to direct SREBP to proteasomal degradation through an ERAD-independent mechanism in yeast, is implicated in EGAD

doi: 10.1016/j.jhep.2018.02.024 43 GuimaraesN