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While cranial window implantation has been associated with inflammation-induced spine turnover (Xu et al., 2007) for more than 20 days post-surgery, cranial thinning in turn does not require a recovery period, is less associated with inflammation and allows immediate imaging (Yang et al., 2010)

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If you experience any severe symptoms outside of minor swelling or bruising at the injection site, including significant pain at the injection site that has not gone away by the next day, call your doctor immediately.

539 Results from several Phase III clinical trials (ORION-9/10/11, NCT03397121, NCT03399370, and NCT03400800) have shown that subcutaneous injections of inclisiran every 6 months considerably reduce LDL-C levels by 4852%, demonstrating sustained efficacy and good tolerability