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Skipping doses or taking extended breaks can reset the tolerance process, potentially causing reactions to return at previous intensity when you resume

Li CY, Wu XY, Tong JB, Yang XX, Zhao JL, Zheng QF, et al

(PMC) Environmental toxicants & heavy metals why we test (and how) Environmental toxicants (heavy metals, pesticides, persistent organic pollutants) can modulate immune function and clearance pathways

Communications Biology, 8 (1), 1-10

Yes, you can administer the injection yourself, but it is recommended to do so under the guidance of a healthcare professional to ensure proper technique and dosage