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The answer involves MTHFR mutations

stage 3 n = 476)

SARS-CoV-2 S-protein shows varying states of conformational shifts of the RBD site progressing towards proteolytic processing, making the viral RBD more accessible to ACE2, with the cleavage at the S1/S2 leading towards RBD open confirmation and viral internalization [33, 34]

Phenylpropanoid and flavonoid biosynthesis play a vital role in the biosynthesis of flavonol aglycones and flavonol glycosides

However, there are no specific histopathology features for morphea and routine histopathology can neither differentiate among the various types nor to distinguish it from SSc (95)