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**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A

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APAP toxicity could be due to the ingestion of a single overdose or too frequent doses with therapeutic intent ( It has been documented that PA administration provided protection through metal chelation and its antioxidant properties ( The present data based on APAP-induced hepatotoxicity in mice identified that PA treatment for 7 days at a dose of 200 mg/kg/day has critical actions in modulating APAP-induced liver toxicity in mice

doi:10.3109/0886022x.2012.723661

doi: 10.1016/j.fct.2019.110646 110 FranzaLCarusiVNuceraEPandolfiF