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Matos J, Cardoso C, Bandarra NM, Afonso C

A Cochrane systematic review of randomized trials for melasma found combination therapy more effective than single agents (a Cochrane systematic review of randomized trials for melasma), and a study in Middle Eastern skin confirmed a tretinoin and hydroquinone combination was effective and tolerated in deeper skin tones (a study of a hydroquinone and tretinoin combination for melasma in deeper skin tones)