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systematic review highlighted concerns regarding the quality of studies on the prevention or treatment of fracture non-union, pinpointing issues like lack of method standardization, inconsistent outcome measures, and inadequate reporting, which currently hampers the feasibility of meta-analyses [4]

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This demethylation leads to destabilization of the mRNA, resulting in reduced CHAC1 protein levels and inhibition of ferroptosis

A significant area of ongoing research focuses on the development of novel exogenous delivery methods for macromolecule transport, including intranasal routes and nanocapsule technologies, with the aim of overcoming pharmacokinetic barriers [46]

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