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Mutation loads in different tissues from six pathogenic mtDNA point mutations

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374 Similarly, in TP53-deficient glioblastoma mouse models, tumor growth inhibition, immune response enhancement, and tumor immunogenicity increase, especially the elevated tumor cell surface expression of PD-L1, which has been suggested to reflect therapeutic response to anti-PD-1, 375 was observed in combination treatment of a nanocomplex encapsulating p53 plasmid DNA with anti-PD-1 compared to anti-PD-1 blockade alone