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It can be observed that proglucagon is not expressed by a single gene, but is embedded in a larger gene, and when this large gene expresses a large peptide chain (called preprohormones), it is then cleaved by specific enzymes and post-translationally modified to finally obtain fragments with different biological activities

Moreover, according to recent studies, alterations of O-GlcNAcylation in various neuronal proteins are found in aging-related neurodegenerative diseases, including Alzheimers disease (AD) and Parkinsons disease (PD) 52,53

& Mohammadi, M

therefore, the inhibitory activity of nanoparticles against P

This occurs through the action of mobilized FAs that function as allosteric activators of uncoupling protein 1 (UCP1), the molecular mechanism for heat generation in brown fat (6, 100)