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This state of immune-tolerance derives from multiple mechanisms such as the mucus barrier minimizing the contact between intestinal microbiota and IECs, and the secretion of antimicrobial peptides like lysozyme, defensins, and immunoglobulin A [10]

Once administered, ALA injections are quickly absorbed and distributed throughout the major organs

Vigorous shaking creates foam, which means air is being forced into the solution, and the mechanical stress of bubble formation can denature the peptide

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