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Furthermore, in advanced liver fibrosis, the contractility of activated HSCs and myofibroblasts promotes liver sinusoidal contraction, affecting blood flow and nutrient exchange, exacerbating liver dysfunction

Cell 154 , 442451 (2013)

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100,120,121,122 An N-terminal intrinsically disordered peptide sequence has been shown to bind another haem moiety, although its function remains to be determined

This interference sensitizes tumor cells to chemotherapy and improves treatment efficacy in preclinical cancer models, positioning RP101 as a candidate for combination therapy approaches