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261 In an uncontrolled trial in 47 subjects with fibromyalgia, 400 mg of oral SAMe twice daily plus 200 mg of intramuscularly injected SAMe once daily for six weeks decreased tenderness, increased general well-being, and improved scores measuring depression, anxiety, and mood

Haddad HW, Mallepalli NR, Scheinuk JE, Bhargava P, Cornett EM, Urits I, Kaye AD

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Balance Problems: In severe cases, individuals may have difficulty walking or experience unsteadiness