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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

ZhangYXuDQiHYuanYLiuHYaoSet alEnriched environment promotes post-stroke neurogenesis through Nf-b-mediated secretion of Il-17a from astrocytes

Its not an approved drug either but it sure looks like one

(2015) reported that DHA prevents A aggregation in APP/PS1 transgenic rat model of AD, but also suggested to combine DHA with other medications because DHA still increases less toxic fibrillar A oligomers