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For example, LGG has protective effects on bone microstructure, bone biomechanics, and related biomarkers (such as CTX-I, PINP, Ca, and RANKL) in an OVX rat model (213)

It can also be modulated by some extrinsic factors such as UVR

Bai J, Zheng Y, Yu Y (2021) Urinary kynurenine as a biomarker for Parkinsons disease

We applied an unsupervised principal component analysis (PCA) to assess class (genotype and/or treatment) homogeneity and to identify outliers, and then, we used a supervised OPLS-DA (orthogonal partial least squares discriminant analysis) to evaluate class discrimination and highlight metabolic differences associated with Tbx1 mutation

HORIZON Investigators of the Huntington Study Group and European Huntington''s Disease Network