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For instance, berberine, a natural compound, downregulates the expression of SLC1A5 in Hep3B and BEL-7404 cells, inhibiting Gln uptake and consequently suppressing expansion of liver cancer cells and tumor progression in vivo (77)

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Any observed nuclear accumulation or nuclear effects of OCTN1 substrates are more likely mediated indirectly following cytosolic uptake, rather than through direct nuclear transport by OCTN1