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The combination of BSO+L-PAM achieved synergistic cytotoxicity (combination index number (CIN) 0.7) and induced 24 logs of cell kill in all nine MM cell lines including the eight lines established at progressive disease (PD) after therapy (U266, OPM-2, NCI H929, KMS-12-PE, EJM, TX-MM-030h, MM.1S and MOLP-2), 25 which include lines with cytogenetic profiles associated with a poor prognosis (Figure 1b)

The first-eluting diastereomer was designated as Example 23, and the second-eluting diastereomer as Example 24

Dosage, method of administration, and the persons existing health condition are determining factors in terms of safety

Study on the protective effect ofpuerarin on alcoholie fatty liver in mice