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10.1146/annurev.arplant.47.1.127

The adaptor protein DDB1 (DNA damaging-binding protein 1) binds CULLIN4A/B-RBX1 complex and interacts with multiple WD40-repeat proteins (WDRs) to regulate cell cycle progression and DNA damage response 8

Pulmonary vascular disease in the developing world

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The most serious risk, lactic acidosis, is extremely rare (estimated at 1-5 cases per 100,000 patient-years) and occurs almost exclusively in patients with severe kidney impairment or acute illness