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As each NADH and FADH 2 molecules generates 2.5 and 1.5 ATP respectively, complete oxidation of one molecule of glucose produces 30 or 32 ATP, depending on the transport of cytosolic NADH to mitochondria either in the malate-aspartate or in the glycerol 3-phosphate mitochondrial shuttles (Voet and Voet, 1995)

Methylmalonic Acid (MMA) Test : An elevated level may suggest B12 deficiency

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Its often accompanied by other medical conditions that can also aggravate symptoms

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases