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Both osteocalcin and matrix Gla protein (MGP) are vitamin K-dependent proteins (93)

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This review summarizes the primary mechanism of GC chemoresistacne and focuses on mechanisms of enhancing chemotherapy sensitivity and reversing drug resistance in TCM from the standpoint of the signaling pathways, which include PI3K/Akt, NF-kB, MAPK, P53, STAT3, TGF-, Nrf2, and Wnt/b-catenin, thereby affecting various biological processes, such as cell cycle, cell proliferation, migration, apoptosis, autophagy, ferroptosis, TME, EMT, DNA damage repair, and cell stemness ( Table 1 )

Wang DS, Wang ZQ, Chen G, Peng JW, Wang W, Deng YH, et al