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This research was funded by Kunming Medical University Alliance Special Project (No.202501AY070001-233), Yunnan Provincial Department of Education Scientific Research Fund (No.2024J0310), Talent cultivation Program of Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences (No.2024RCTJ-QN-005, No.2025YFKT-PY-07, No.2025YFKT-ZL-10), the Yunnan Provincial Clinical Medicine Research Special Program (No.202405AJ310003)