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10.1371/journal.pone.0131224 220 WengC.-H.HuC.-C.LinJ.-L.Lin-TanD.-T.HuangW.-H.HsuC.-W.et al

For that, we used the pathway activity analysis tool PROGENy 41 , which calculates pathway activity scores based on pathway regulons: a set of genes whose expression is influenced by pathway activation or inhibition