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Whereas initial studies suggest that its expression in the proximal tubules is very low, recent studies using microdissected, freshly-isolated, murine, nephronic segments demonstrated the highest IGF-1R mRNA expression in proximal tubules along the nephron [11]

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The animals were randomized into three groups and subcutaneously injected with rhGH (1 or 2 IU/kg) or 0.1 mL of saline every morning at 11 a.m