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By contrast, despite promoting increased ROS production, human cytomegalovirus (HCMV) infection positively modulates Nrf2 expression

These proteins contain selenocysteine, an amino acid that is strategically positioned within the enzymes active site, enabling their antioxidant activity [8, 9]

This emanates from the fact that synthetic drugs are designed for just a purpose (for instance, treatment of a particular disease) and targeting a certain pathway and mechanism, while a large number of studies have revealed that naturally-occuring compounds are capable of affecting a wide variety of molecular signaling pathways (Guo et al., 2019

doi: 10.1007/s11239-012-0759-x

Histamine also upregulates NE