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As reported, alterations in the ECM during developmental organogenesis, homeostasis, and injury repair can alter lung structure and are often involved in bronchopulmonary dysplasia, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis

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The synergistic recovery of SOD2 and GSH-Px is particularly crucial in this process, as they jointly regulate mitochondrial ROS levels: SOD2 is responsible for clearing superoxide anions, while the latter (GSH-Px) removes the H 2 O 2 generated by their disproportionation