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Treatment fidelity To determine whether treatment is delivered as intended, all music therapy sessions will be videorecorded to allow assessment by trained, independent assessors who will not be involved in collecting outcome data or providing the intervention

Procedure for dual functionalization of C3 enzyme To the Cys-C3bot1 solution (0.372 mg/mL in 50 mM PB, pH 7.4) (300 L, 0.0045 mol), compound 6 (25.0 mg/mL in DMF) (20 equiv, 2.00 L, 0.090 mol) was added and the resultant mixture was incubated for 5 h at 20C