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Patients should introduce such supplements gradually and monitor tolerance

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These include abnormally increased sympathetic nervous system activity and circulating catecholamines resulting in a hyperadrenergic state (hyperadrenergic POTS), peripheral sympathetic denervation leading to venous pooling and volume dysregulation (neuropathic POTS), low blood volume (absolute hypovolemia) and an underlying immune dysregulation (discussed in further detail below)

Exosomes derived from mesenchymal stem cells can cross the BBB and deliver trophic factors, thereby replicating many of the protective benefits of stem cells without risks such as tumorigenesis or embolization