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Notably, emerging evidence suggests that excitotoxicity may synergize with immune dysregulation, exacerbating neuronal vulnerability and accelerating disease progression [99]

In addition, while our study provides proof of concept for the potential of intranasal PEVs in TBI and PD, future preclinical studies must consider the severity of these diseases to define the optimal volume and dosing of administration

The IHC-LAR subtype demonstrates the HER2 signaling pathway activation, and the IHC-IM subtype presents an immunoinflammatory phenotype, which is characterized by the infiltration of CD8 + T cells into the cancer parenchyma

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