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Description

Extracellular L-lactate, either generated from glucose or from glycogen, binds to HCAR1, a specific receptor that is abundantly localized in perivascular and post-synaptic membranes and regulates synaptic plasticity

Clinical and experimental studies have consistently demonstrated that PRLM levels are markedly reduced in the cerebrospinal fluid and affected brain regions of patients with NDDs, with lower levels correlating with more severe cognitive decline