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After cleaning the area with an antiseptic solution, local anesthetic is infiltrated subcutaneously at the needle insertion site

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Nevertheless, the overarching conclusion is that while Daratumumab moderately affects CD38s in vitro cyclase activity, Isatuximab exerts a stronger effect

When assessing for vitamin B12 deficiency, in addition to checking a vitamin B12 level, consider ordering a methylmalonic acid level or a holotranscobalamin level and CBC (to assess for red blood cell size)