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Plant Physiol Biochem 47:10821088 AOAC (2000) Official methods of analysis

Because the concentration of PQ in the brain following acute exposure is low, the possibility of neurotoxicity by PQ was overlooked in earlier studies as it was thought that the blood-brain barrier (BBB) would impede PQ entry into the brain

You can also take glutathione via inhalation or injection

But reduced production tells only half the story