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The numerator components for the Emergency Care Access & Timeliness eCQM are described in detail in section XVI.B.1.c

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MTHFR polymorphism and psychiatric diseases Extensive clinical studies demonstrated a significant linkage between MTHFR polymorphism and various diseases, such as cardiovascular diseases, neuronal developmental diseases, cancers as well as psychiatric disorders

Research on this connection remains limited

These are the different types of potential variations to look for: Homozygous variation You have two copies of the same MTHFR variation (either two variations on 677 or 2 variations on 1298)