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We used a discovery approach to systematically map an atlas of the associations of GLP-1RA use versus each comparator with 175 health outcomes

Specifically, when permeability (as measured by the cell ratio, defined as the cellular EC 50 / Mdm2 K D ), was plotted versus peptide helicity, we noted that peptides with poor cell ratios (400 or greater) also had low helicity values ( 3) was not a practical path to the clinic as these molecules also displayed poor solubilities (often 10x loss in cellular potency when tested in the presence of 10% FBS (Supplementary Table 3)

Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ

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