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In his review in Blood, Ralph Green hematologist, Department of Pathology and Laboratory Medicine, University of California, Davis, recommends at least 10mcg/day of daily vitamin B12 to prevent problems

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It is important to note that the activation rate of Met upon binding to HGF is assumed to be independent of the 51 binding, but the rates of internalization, degradation, and recycling of the receptor were assumed to be dependent on 51 binding

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Funding This study was supported by the National Natural Science Foundation of China (82370613), the National Key R&D Program of China (2023YFC2306800), the National Natural Science Foundation of China (82270624, U24A20773) and the Independent Task of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases (zz202314)