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4.2.1.2 Cytokine targeting nanoparticles Another nanoparticle approach targeted chemokinedriven immunosuppression

used off-label for adult GH deficiency management), tesamorelin (FDA-approved for HIV-associated lipodystrophy under the brand Egrifta SV), and mecasermin (approved for severe primary IGF-1 deficiency in children) [15, 19]

Key takeaway: Suggests possible relevance for joint and connective tissue research

Chaplin MF (2012)

Longitudinal spinous-splitting laminoplasty with coral bone for the treatment of cervical adjacent segment degenerative disease: a 5-year follow-up study