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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

2019 Sep 30;11(10):2315

Advertisement Research ArticleMetabolismMuscle biology Open Access | 10.1172/JCI181881 1 Department of Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, 2 Department of Molecular and Medical Pharmacology, Faculty of Life Sciences, and 3 Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan