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Similarly, polymer N 3 -PEG 3.4K -PDHD was treated likewise to obtain BBB-bindable nanoprobe ApoE-PDHD@ILD & R848 after adding ApoE-DBCO

FIGURE 4 7 Conclusion Many in vitro , in vivo , and pre-clinical studies have demonstrated various effects of metformin, such as anti-diabetic, antioxidant, anti-inflammatory, anti-tumor, and cardioprotective effects in gynecological disorders, which are mainly due to the effects on the IGF system and several intracellular signaling transduction pathways, such as AMPK, PI3K/AKT/mTOR, and MAPK/ERK pathways

Schmid M, Walsh K, Webb R, Rijpstra WI, Van de pas-Schoonen K, Verbruggen MJ, hill T, Moffett B, Fuerst J, Schouten S

Their findings suggested that these bioactive compounds hold promise as potential drugs for NAFLD treatment