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For instance, studies on Nrf2 knock-out mouse embryo fibroblasts have shown increased activity of IKK and degradation of IB (138)

Leone, I.M

Cancer 20, 128

Inhibition of key KRAS upstream and downstream molecules can also effectively inhibit KRAS-mediated signal transduction, such as inhibiting upstream signalling, SHP2, and inhibiting downstream signalling, the RAF-MEK-ERK pathway and the PI3K-AKT-mTOR pathway