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As shown in Table 3, the unique properties of nanomaterials have led to the rapid development of metal-based cell death pathways in HNSCC treatment

(2019) Role of GPX4 in ferroptosis and its pharmacological implication, Free Radic

radicals and toxins, helping to keep our system clean

Activation of HIF-1 signaling by PHD2 deletion under normoxia enhanced glutamine uptake and upregulated GLS1 expression leading to enhanced glutaminolysis and increases in cellular GSH levels and in GSH/GSSG, which correlated with upregulation of antioxidant genes ( SOD1 , SOD2 , catalase , GPx1 , and GR ) and reduction in cellular and mitochondrial ROS production, indicatives of reductive stress (96)