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Emerging therapies, including TYK2 and RORt inhibitors, offer new hope with potentially improved safety margins, yet their long-term hepatic effects remain to be fully elucidated

Bhrigu, B., Sharma, S., Kumar, N

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86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)