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For chewable tablets or powders, changes in taste could result from degradation of active ingredients, exposure to moisture or heat, contamination, or aging, and should prompt discontinuation if accompanied by other spoilage signs

Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol

Aggarwal V, Tuli HS, Tania M, et al

Preparation of the GBL derivative has the advantage of easier extraction into organic solvents and better chromatographic separation properties with sharp peaks and good linearity over a wide concentration range of 5-1000 mg/L [95]

With no published human half-life, there is no validated missed-dose rule