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This effect often diminishes with continued use as the system adapts

it does not mean senolytics cause cancer, but it highlights that the biology of senescence is not uniformly harmful and that senolytic intervention requires careful therapeutic window definition

In a subanalysis of SURPASS-3, tirzepatide 10 and 15 mg resulted also in a relative reduction in liver fat content by 4047% compared to 11% with insulin glargine at 52 weeks [44]