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[8] Reproductive Effects Chronic ipamorelin treatment in young female rats influenced reproductive parameters including follicular development and hormonal cycling, suggesting that GH secretagogues interact with the hypothalamic-pituitary-gonadal axis

Crofford, Implications of glucocorticoid therapy in idiopathic inflammatory myopathies, Nat

Unlike synthetic HGH (which suppresses your bodys own production), this combination stimulates your pituitary to release more of its own growth hormone maintaining the pulsatile pattern that makes GH physiologically effective