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In aged mice, the team found that all three organs had glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy (difficulty in disposing damaged mitochondria), impaired nutrient sensing and genomic damage

Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils

Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans

Intracellular iron deposition is present and associated with these pathological features long before development (Goodman 1953

Mol Neurobiol 61(1):294307 Wu L, Xiong X, Wu X et al (2020) Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury